He began his career with a series named Flashpoint in a role of Michelangelo "Spike" Scarlatti until the show ended on December 13, 2012.
After making his debut in the 1995 film Senior Trip, Di Zio appeared in a string of telepics including The Wall, Major Crime, Freak City, Rembrandt: Fathers & Sons, and RFK.
Additionally, he guest starred on other Canadian series, such as Murdoch Mysteries, Republic of Doyle, and even played "Ripper" on Stoked for 11 episodes.
Film appearances include Ron Howard's Cinderella Man, Boondock Saints, Flash of Genius, and the Independent Spirit Awards winning The Lookout, playing Deputy Ted.
Di Zio has starred in Just Buried, 19 Months and the Peter Wellington film, Luck, winner of the South by Southwest Film Festival.
He has won Gemini Award in a category of Best Performance .